Abstract: Currently, cotton fabrics are widely used in the sock industry due to their skin-friendly softness, excellent moisture absorption, and breathability. However, cotton socks are prone to microbial growth during wearing, as the hot and humid wearing environment greatly facilitates the rapid reproduction of fungi and bacteria. The proliferation of various fungi not only adversely affects the cotton sock fabric but, more importantly, poses a threat to foot health. Scopulariopsis brevicaulis is a ubiquitous opportunistic pathogen and one of the common pathogens causing onychomycosis of the foot. 
In this study, Scopulariopsis brevicaulis isolated and purified from worn cotton socks was inoculated onto pure cotton white socks and human nail plates to investigate its corrosive effects on cotton fibers and nail plates. SEM, FT-IR and XRD tests were conducted on the cotton socks corroded by Scopulariopsis brevicaulis under three different conditions to analyze the damage to the cotton fabric before and after corrosion. The results indicated that the cotton sock fabric was most severely corroded under nutrient-rich conditions. SEM images revealed extensive longitudinal stripes and gullies on the surface of the cotton fibers, along with severe adhesion between fibers. The results of FT-IR and XRD showed that some of the 1,4-glycosidic bonds within the corroded fibers broke, and the crystallinity of the fibers decreased from 54.54% to 45.51%. In addition, tensile tests were performed on the cotton yarn before and after corrosion, which showed a 68% reduction in yarn breakage. Besides, the penetration ability of different concentrations of Scopulariopsis brevicaulis solution to healthy nail plates was studied by constructing a fungal nail penetration model. The results showed that the bacterial solution of 1×104 CFU /mL, 1×106 CFU /mL and 1×108 CFU /mL were all capable of penetrating the nail plates. Among these, the condition of 1×108 CFU/mL exhibited the shortest nail penetration time, requiring only two days. Furthermore, by observing SEM images of the eroded nail plates, it was evident that Scopulariopsis brevicaulis caused severe damage to the keratinocytes on the dorsal surface of the nail plates, with numerous pores and gaps appearing on the surface. Some hyphae even directly penetrated through the nail plates.
 Therefore, all the above experiments indicate that Scopulariopsis brevicaulis exhibits certain corrosive properties towards both cotton sock fabrics and human nail plates. Conducting research on the biological corrosion of Scopulariopsis brevicaulis in the foot-sock microenvironment provides basic support for its targeted inhibition.

Key words: Scopulariopsis brevicaulis, cotton socks, nail plates, nail penetration model, microbiological corrosion

摘要： 为了分析足-袜特定微环境中短柄帚霉的生物腐蚀性，培养了从穿戴后棉袜中分离出的短柄帚霉，并将其接种在纯棉白袜和甲板上，开展短柄帚霉对棉织物和甲板的腐蚀性研究。通过扫描电子显微镜、傅里叶红外光谱、X射线衍射以及材料试验机对短柄帚霉腐蚀过的棉袜进行织物和纤维损伤表征，探究了3种不同条件下短柄帚霉对棉袜织物的腐蚀情况；通过构建真菌透甲模型，并结合扫描电子显微镜技术，探讨了短柄帚霉在体外对健康甲板的侵蚀。结果表明：在富集营养条件下，经短柄帚霉腐蚀的棉袜织物损伤严重，腐蚀后棉纤维表面出现较多纵纹沟壑，分子结构发生了变化，结晶度下降了9.03%，且棉袜纱线的断裂强度下降了68%。同时，甲板侵蚀实验结果显示，不同浓度的菌悬液均能穿透甲板，当菌悬液浓度为1×108 CFU/mL时，最短透甲时间为2 d。该研究结果表明短柄帚霉对棉袜织物和甲板具有一定的腐蚀性，为开发具有靶向抑菌的功能材料提供了参考。

关键词: 短柄帚霉, 棉袜, 甲板, 透甲模型, 微生物腐蚀