Abstract: In order to explore the role of conductive materials in the repair of peripheral nerve injuries, so as to develop a conductive nerve catheter that can replace autologous nerve transplantation, relevant researches at home and abroad in recent years are reviewed. The mechanism of electrical stimulation to promote axon regeneration and the nerve regeneration on conductive substrates are discussed. The application of conductive materials such as polypyrrole, polyaniline, and graphene in nerve conduits is introduced, including the composite method of conductive materials on the conduits, application characteristics, in vitro and in vivo test results, etc. It is pointed out that in the future research on conductive nerve conduits, we should pay attention to and solve the problems of conductive materials that are difficult to process and hard to degrade, as well as the long-term metabolic mechanism and physiological toxicity of conductive materials in vivo and their role in long-distance nerve injury repair.

Key words: nerve conduits, conductive materials, peripheral nerve injury, nerve regeneration, electrical stimulation

摘要： 为深入探究导电材料在周围神经损伤修复中的作用,开发出能够代替自体神经移植的导电神经导管,对近年来国内外相关研究进行了综述。探讨了电刺激促进轴突再生的机制和导电基材上的神经再生情况,介绍了聚吡咯、聚苯胺、石墨烯等导电材料在神经导管中的应用,包括导电材料在导管上的复合方法、应用特点、体外体内试验结果等。指出未来导电神经导管的研究中应关注与解决导电材料难加工、不易降解,以及导电材料在体内的长期代谢机制与生理毒性及其在长距离神经损伤修复中的作用等问题。

关键词: 神经导管, 导电材料, 周围神经损伤, 神经再生, 电刺激